Factors driving co-occurrence of Schistosoma mansoni and S. haematobium at the micro-geographical level
نویسندگان
چکیده
Methods and materials A multidisciplinary study was conducted in two neighboring rural communities in northern Senegal, where S. mansoni and S. haematobium are co-endemic (n=857). Kato-Katz and urine filtration were used for microscopic detection of the respective Schistosoma species. Households were located using handheld differential global positioning system in the largest community (n=599), and the Kulldorff’s scan statistic was used to detect spatial clusters of infection. Schistosoma-specific cytokine responses (IL-10, IL-5, IFN-g, TNF-a, and IL-2) were assessed in 72h whole blood culture supernatants (n=200), and analyzed by the multivariate technique nonmetric multidimensional scaling (nMDS).
منابع مشابه
Micro-Geographical Heterogeneity in Schistosoma mansoni and S. haematobium Infection and Morbidity in a Co-Endemic Community in Northern Senegal
BACKGROUND Schistosoma mansoni and S. haematobium are co-endemic in many areas in Africa. Yet, little is known about the micro-geographical distribution of these two infections or associated disease within such foci. Such knowledge could give important insights into the drivers of infection and disease and as such better tailor schistosomiasis control and elimination efforts. METHODOLOGY In a...
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